The US study found that the combination of existing drugs can be used to fight cancer. Researchers at Brigham and Women's Hospital in the United States said that the new comprehensive therapy obtained by combining multiple drugs is expected to treat two highly aggressive tumor diseases. Before this, people were almost helpless to these two tumor diseases. When developing anti-cancer drugs, people found that existing drugs alone had no effect on many tumors. To this end, researchers at Brigham and Women ’s Hospital envision combining different drugs and letting them work together to combat cancers that are difficult to treat. After testing, they successfully found a combination of drugs for the treatment of neurological tumors associated with multiple neurofibromas and KRAS variant lung cancer. KRAS variant lung cancer accounts for 25% of all lung cancer incidence. Articles about the new findings were published in the journal Cancer Cell published on September 13. The researchers' new therapy combines two drugs, they are the mTOR inhibitor rapamycin that can inhibit tumor growth and the HSP90 inhibitor IPI-504 produced by Infinite Pharmaceuticals that can cause cancer cells to develop a special stress state. Experiments performed on the experimental mice using the combination of the two showed that the tumors of the nervous system and KRAS variant lung cancer associated with multiple neurofibromatosis A showed obvious contraction. Dr. Karen Sidrosky, associate professor of genetics at the hospital, explained that using combination drugs to treat cancer is like dealing with tumor cells from two different angles. Under the double pressure of drugs, tumor cells eventually self-destruct. The new research results inspire researchers to test the combination drugs, and have entered the first phase of clinical trials, especially the combination drugs for the treatment of KRAS variant lung cancer. Karen believes that the new combination of drugs to treat two types of cancer has laid the foundation for people to find other combination drugs, and is expected to help develop effective ways to treat other cancers. Karen said that before finding an effective drug combination, people have used chemotherapy to treat the above two tumors and the probability of success is not stable. The success rate and survival rate of these two cancers treated with targeted combination drugs are expected to be greatly improved, and patients will also avoid the side effects of chemotherapy.
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