This study is the first documented to demonstrate that goat milk with a higher concentration of antimicrobial lysozyme can successfully treat diarrhea caused by bacterial infections of the gastrointestinal tract. Protein found in milk.
The research results are planned to be published in the online version of the scientific journal PLOS ONE on March 13th. These findings provide hope that this milk will eventually help prevent human diarrhea; diarrheal diseases will take 1.8 million people around the world every year. Children ’s lives and impair the physical and mental development of millions of other children.
James Murray, a professor of animal sciences at the University of California, Davis and the principal investigator of this study, said: "Many developing regions of the world rely on livestock as their main food source. These results are just an example, that through genetic engineering, we It can provide agriculture-related animals with new characteristics; the goal of these characteristics is to solve some health-related problems facing developing societies. "
In this study, Murray and colleagues fed goat milk to young pigs. These goats were genetically modified to produce milk with a higher concentration of lysozyme, which is a natural occurrence in all Proteins in mammals' tears, saliva and milk.
Although human milk contains very high concentrations of lysozyme, goat and dairy cow milk contains very little lysozyme, which prompts researchers to use genetic modification to increase the concentration of lysozyme in goat and milk water .
Because lysozyme can limit the growth of certain bacteria that cause intestinal infections and diarrhea, and it can also promote the growth of other beneficial intestinal bacteria, it is considered to be the main reason for the health and physical and mental health of breast-fed infants. One of the ingredients of human milk.
Pigs were chosen as the research model in this study because their gastrointestinal physiology is quite similar to that of humans, and pigs have produced an appropriate amount of lysozyme in their milk.
In this study, half of the pigs were fed with pasteurized milk from these genetically modified goats, which contains a large amount of lysozyme-equivalent to 68% of the amount of lysozyme in human breast milk. The other half of the pigs are fed pasteurized milk from non-GMO goats, and the milk contains very little lysozyme.
The study found that although both groups of pigs recovered from the infection and the diarrhea it caused, those younger pigs fed lysozyme-rich milk recovered faster than those who received goat milk that did not increase the amount of lysozyme Older pigs recover much faster. In general, pigs fed lysozyme milk had less dehydration, less intestinal inflammation, less intestinal lining damage, and faster energy recovery than control pigs. Moreover, the researchers found no adverse reactions related to lysozyme-rich milk.
The lysozyme-increased milk used in this study came from a transgenic strain of goats. They were developed by Murray, co-author of this article, Elizabeth Maga, and colleagues. They carry human lysozyme in their milk Enzyme genes.
Other researchers involved in this study are: Caitlin Cooper, Lydia GarasKlobas, and Elizabeth Maga, all from the Department of Animal Science at the University of California, Davis. Funding for this research was provided by the College of Agriculture and Environmental Sciences at the University of California, Davis and the University of California Agricultural Experiment Station.
About the University of California, Davis:
UC Davis has been engaged in teaching, research, and public affairs related to California that can transform the world for more than 100 years. The University of California, Davis is located near the capital of California. It has more than 33,000 students, more than 2,500 faculty, and more than 21,000 employees; its annual research budget is close to $ 750 million and has a comprehensive medical system and 13 specialized Research center. The university offers interdisciplinary graduate school study and offers more than 100 undergraduate majors in four colleges—the College of Agricultural and Environmental Sciences, the College of Biological Sciences, the College of Engineering, and the College of Literature and Science. It also has six professional colleges-School of Education, School of Law, School of Management, School of Medicine, School of Veterinary Medicine, and Betty Irene Moore School of Nursing
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