Shanghai Yili told you: Scientists have discovered a new active substance that can inhibit the cell division of leukemia cells, suggesting that the active substance may play an important role in the fight against cancer.
The substance XD14 can inhibit the function of several proteins in the BET family, and can inhibit protein transmission signals, such as the signals that trigger cell division.
In the case of leukemia, genetic mutations can cause transduction that interferes with the above signals: cells will continue to divide without control, thereby damaging the entire body. Scientists use virtual screening to discover new drugs: The bioinformatics research team led by Stefan Günther studied the properties of tens of millions of molecules in a computer model.
Their goal is to find some substances whose binding force is strong enough so that they can prevent certain proteins of the BET family from transmitting signals. Among them, scientists tested the effect of one of XD14 on 60 different types of cancer cells. Experiments show that XD14 can significantly inhibit the cell division of leukemia cells. They are investigating whether the molecule is suitable for drug development.
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