Just as Chutian people celebrated the sixth anniversary of the establishment of Chutian with the joy of victory, the 2006 National Spring Exhibition of Pharmaceutical Machinery followed suit. Chutian set 60 booths in one fell swoop, and participated in a strong line-up of 7 main engines and 26 stand-alone machines. Among them, the powder liquid double-chamber bag infusion line, the high-speed glass bottle infusion line, and multiple domestic new stand-alone machines and other international advanced technologies have become new highlights of the Chutian show. The following is a detailed description of the powder and liquid double chamber bag infusion technology.
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The infusion packaging form has undergone the following stages in its development: glass bottle infusion - plastic bottle infusion - PVC soft bag infusion - non-PVC soft bag infusion - liquid liquid double chamber bag infusion - liquid Liquid multi-chamber bag infusion - powder liquid double room bag infusion. Powder Liquid Double-chamber Bag Infusion Currently, only Japan's Otsuka has formed mass production, and it has already entered the market and is temporarily in a leading position. German powder liquid double-chamber bag infusion is still in small batch production and is still in its infancy. Due to the greater advantages of the conventional dual-chamber bag infusion compared to conventional methods of dispensing, the majority of pharmaceutical and hospital approvals have been achieved. Many domestic pharmaceutical factories and soft bag infusion production line manufacturers invested a lot of funds for R&D at the end of 2004. In the past two years, they have made certain breakthroughs, and prototypes and samples have appeared.
The powder liquid double-chamber bag infusion is also known as a ready-to-use infusion in China. The infusion is to pack the powdery drug and the injection solvent together, and to connect it in some way. When it is used, it is rotated, squeezed, broken, etc. The two substances are connected and mixed before use. The traditional method of mixing requires needle puncture, and its medication safety is not very high. The comparison of the two infusion forms is as follows:
project
Powder double chamber bag infusion
Traditional powder liquid infusion
Pharmaceutical environmental requirements
No special dispensing room is required, ready to use, low environmental requirements, especially adapted to war environment and environment without dispensing room
Dedicated pharmacy room is required. It can't be used immediately. It has high environmental requirements.
When used twice
Secondary pollution
Only the infusion pipeline may have secondary pollution during use
When the needle is used for multiple punctures during use, there is an increase in the chance of particles, and there is a possibility of secondary pollution when the infusion line is used.
Dispensing with air
Contact situation
No contact with air when dispensing, the environment does not contaminate the drug, and there is no drug loss
Contact with air at the time of dispensing, the environment may pollute the drug, and there is drug loss
Possibility of mis-dispensing
No mis-dispensing, high safety
There is a possibility of mis-dispensing and the safety is not very high
Health care staff safety
Reduces the potential harm to chemotherapy and other drugs to medical personnel by reducing the drug exposure
Due to the large number of pharmaceutical contact drugs, drugs such as chemotherapy are potentially harmful to medical personnel.
Environmental protection
CO2 and H2O are only produced when the waste is burned after use, causing less environmental pollution
It can produce toxic substances when it is burned after use, and it is harmful to the environment.
market expectation
It is in its infancy, there are few competitors, and the market has good prospects and great potential for development.
At the stage of fierce competition, with many competitors, the market outlook is not optimistic
Profit margins
High product added value, large profit margins
Most of the value-added products are not high, and the profit margin is not large
investment risk
Large equipment investment, high risk
Low investment in equipment and risk
There are three main types of powder and liquid infusions that are being developed in China. One is a dual-chamber bag with intermediate cold welding, the other is a single-chamber bag with a charging interface (pipe suspension), and the other is the middle of the belt. The valve is welded with double room bags. The three forms of performance comparison are as follows:
project
Middle Welded Double Room Bag
Single room bag with charge interface
Solid double room bag with middle valve
source of technology
Japanese technology
Innovation
Innovation
Shape features
Double liquid powder chamber, aluminum powder protection membrane, slender structure
The powder is installed in the tube, the liquid is packed in the bag, and the structure is short
Double liquid powder chamber, aluminum foil powder room protection, middle valve, slender structure
The main process
Bags - Aluminium Film - Filling - Sealing - Sterilization - Lamp Inspection - Open Bags - Filling Powder - Sealing - Outsourcing
Bags - Filling - Sealing - Sterilization - Lamp Inspection - Open Interface - Powder Filling - Sealing - Light Inspection - Outsourcing
Bags - Filling - Sealing - Sterilization - Lamp Inspection - Open Bags - Wind Drying - Powder Filling - Sealing - Light Inspection - Laminating - Outsourcing
Powder filling light inspection
Cannot be achieved
Achievable but less visible
Can be realized and has strong visibility
Mixed drugs
External force extrusion
Broken type
Rotary or push type
Mixed drug time
short
general
general
Mixed drug reliability
May not be able to squeeze
reliable
reliable
Possibility of generating particles when mixing drugs
Weld welding is also a two-layer film bonding, which may generate particles when squeezed
Breaking is to forcefully destroy the original structure and increase the possibility of particles
Without destroying the original structure, there is little possibility of particles
Aluminum foil effect
The aluminum film material is more difficult to choose, when the aluminum film is attached, it is possible to change from the virtual welding to the real welding.
Aluminum foil is not applied and the process is reduced.
Reduce costs
The aluminum film material is easy to choose, and there is no way to change from the virtual weld to the real weld when the aluminum film is applied.
Sterilization effect
The use of hot air circulation sterilization, sterilization cabinets require high, long sterilization time,
When sterilizing, it is possible to change from cold-weld to solid-weld or open-weld. The water content in the powder chamber is very small, and it can be filled directly after sterilization.
Water bath sterilizer can be used, the sterilization time is short, the water content in the powder chamber is low, and the powder can be powdered after sterilization.
Water bath sterilizer can be used, the sterilization time is short, the water content in the powder chamber is large, and it takes a long time after sterilization to allow the high temperature hot air to dry before filling the powder.
Before filling
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